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Miguel Castanho to lead project selected for funding by the European Innovation Council

By Joana Ferreira de Sousa On 23 October, 2018 2018 | Research and Advanced Education Comments Off on Miguel Castanho to lead project selected for funding by the European Innovation Council Tags: tile

The European Commission has announced that the European Innovation Council will support an innovative Portuguese project in the area of the fight against highly dangerous viruses with 4.2 million euros. The NOVIRUSES2BRAIN project is led by Researcher and iMM/FMUL teacher Miguel Castanho, in collaboration with a Spanish university (Pompeu Fabra University, Barcelona) a Brazilian university (Federal University of Rio de Janeiro) and also a German company (Synovo Gmbh, Tübingen). Miguel Castanho and his Laboratory will receive a total of 2.1 million euros.

We spoke with the head of this research study and we asked him to comment on yet another piece of excellent news regarding his work. “This funding is very important for several reasons. The most important of all is the nature of the competition, which was aimed at developing bold, unconventional ideas, which generate innovative solutions to objective problems. We were selected thanks to the innovative character of our ideas. We thought outside the box, as they say. Secondly, this is a considerable amount of funding achieved in a very competitive European competition, which demonstrates the scientific strength and capacity of the iMM-FMUL partnership. Thirdly, because this is the work of an international consortium (Portugal, Spain, Germany, Brazil), but the leadership is ours. We shaped the project, looked for partners, and made it happen. Lastly, because it is a recognition of merit, which is always reinvigorating in an exhausting profession, subject to numerous instabilities, as is that of a researcher. And this merit extends to all those working in the IMM and FMUL for the greater good at all levels without exception, from research laboratories to administrative and technical management.”

Miguel Castanho and the teams that have partnered with him in this project aim at developing an intelligent drug that is able to simultaneously deactivate several types of viruses capable of lodging in the Central Nervous System and causing neurological complications. These viruses include Measles, HIV, Dengue, Zika and Chikungunya. The latter two are latent threats in Portugal because they are spread by mosquitoes of the genus Aedes, , already settled on the island of Madeira and recently found in mainland Portugal. On the other hand, there might be another outbreak of the Dengue virus on the island of Madeira, which may spread to mainland Portugal

Viruses that infect the brain and other parts of the central nervous system are a major worldwide threat. The latest large-scale threat in this area was the outbreak of the Zika virus in South America which, like the Dengue virus or the Chikungunya virus, is transmitted mainly by mosquitoes of the genus Aedes. When a pregnant woman is infected, the virus is able to cross the placental barrier between mother and fetus and then the protective blood-brain barrier of the central nervous system of the fetus, causing microcephaly and other neurological disorders in newborns. Recent news also point to new cases of Zika in Africa; according to a Reuters report published in the Público newspaper, 72 babies were born with microcephaly in Angola between February 2017 and May 2018. It is feared that the Zika virus strain responsible for more than 3,700 cases of birth defects in Brazil since 2015 may give rise to a new strain, predominant in Angola.

Despite the high likelihood of co-infections with Aedes-born viruses, such as the Zika, Dengue and Chikungunya viruses, because several viral species coexist in the same vector, the classical drug development strategies ignore that reality. In addition, additional co-infections with HIV and measles virus are also possible. There is a pressing need for a drug that is capable of neutralising a very broad spectrum of viral species simultaneously.

 

Learn all about this and other projects:

https://imm.medicina.ulisboa.pt/pt/investigacao/laboratorios/castanho-lab/

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Índice – News nº 83 | out. 2018
 Simbioses
 I Updated Course in Medical Law | Opening Session
 Professor António Gonçalves Ferreira elected President of the European Association of Stereotactic and Functional Neurosurgery
 Living daily with cancer – the testimony of Sandra Lucas
 Dark-haired Maria
 Professor Jorge Draper Mineiro – tribute on the centennial of his birth
 Awards Ceremony of the 5th Annual Health + Solidarity Run
 With a balanced heart!
 Uma aula especial dada pelo Professor Mário Simões
 Beyond Med – A Glance at Medical Education
 Opening of the Master’s Degree in Cardiovascular Rehabilitation
 Ronald Harden is granted the Honoris Causa Doctorate by the University of Lisbon
 Personality Award granted to Fernando Pádua, the “Heart Doctor”.
 The hug between iMM and Laço – a conversation with consultant Lynne Archibald
 Open Access International Week 2018 | National and International Policies
 The Mentoring Project and its novelties
 Carmo Fonseca and the Laboratory that wants to wait for cancer before it appears
 Miguel Castanho to lead project selected for funding by the European Innovation Council
 Find the Researcher you are looking for – Now
 Publicações Científicas (FMUL/HSM/IMM) setembro – outubro 2018
 AIDFM CETERA – Ensaio Clínicos
 Anti-measles medicines – a research led by Miguel Castanho
 ERC 2018 Synergy Grants para Edgar Gomes (iMM)
 Sérgio de Almeida and his new weapon in the fight against breast cancer
 Notícias do Pedagógico
 Vera Mendonça – on radiotherapy for breast cancer
 The ancient book of CDI-Library of FMUL: a legacy that honours the past and helps us build the future
 Lecture “Mediterranean Diet: Health Promoter”
 Dia da Investigação | 12 DEZ – Save the date
 XVII Hospital dos Pequeninos
 II Congresso de Investigação em Medicina das Escolas Médicas Portuguesas | 9 e 10 de novembro 2018
 4th Students Meeting of Mind-Brain College
 “Descomplicar a Pesquisa Bibliográfica”
 Deslocado? – Tem o Espaço S
 Já está à venda a Agenda da Pediatria
 José Manuel de Vasconcelos Pequito Cortez Pimentel (1924-2018)
 Dra. Anabela Maria Rebelo Morais (1955–2018)
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100 AnosPropriedade e Edição: Faculdade de Medicina da Universidade de Lisboa NIPC: 502662875  Periodicidade: Mensal  Diretor: Prof. Doutor Fausto J. Pinto Conselho Editorial: Prof. Doutor Fausto J. Pinto, Profª. Doutora Ana Sebastião, Prof. Doutor Mamede de Carvalho, Prof. Doutor António Vaz Carneiro, Prof. Doutor Miguel Castanho, Dr. Luís Pereira  Equipa Editorial:  Ana Raquel Moreira, Cristina Bastos, Isabel Varela, Joana Sousa, Maria de Lurdes Barata, Rui Gomes, Sónia Teixeira  Colaboração:  Gabinete de Relações Públicas, Internacionais e Comunicação  Versão Inglesa: AP|PORTUGAL- Language Services  Conceção: Metatexto, Lda. e-mail: news@medicina.ulisboa.pt  Sede do Editor e Sede da Redação: Avenida Prof. Egas Moniz, 1649-028 Lisboa Estatuto Editorial Anotado na ERC 

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