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New genetic mutations in leukemia: IMM researchers found molecular mechanism that can help design future targeted therapies

By etavares On 31 October, 2011 Research and Advanced Education | 2011 Comments Off on New genetic mutations in leukemia: IMM researchers found molecular mechanism that can help design future targeted therapies No tags

Published in Nature Genetics

Researcher from Cancer Biology Unit of IMM, lead by João T. Barata, have found a group of mutations involved in T-cell acute lymphoblastic leukemia (T-ALL), and showed that certain drugs, already in clinical use to treat other diseases, can eliminate the cells carrying these mutations. Results were published in Nature Genetics and may promote the development of novel therapeutic approaches against leukemia.
The study was led by researcher João T. Barata at Instituto de Medicina Molecular jointly with J. Andres Yunes at Centro Infantil Boldrini in Campinas, São Paulo, Brazil, in collaboration with researchers from the National Cancer Institute in Frederick, Maryland, USA, the Erasmus Medical Center, Rotterdam, The Netherlands; and other laboratories in Europe and the US. This is a basic research study with potential clinical impact, which was performed, in part, using samples from pediatric leukemia patients.

T-ALL affects mostly children. It is a blood cancer consisting in an uncontrolled growth in the number of T-lymphocytes (white blood cells from the immune system). The onset of the disease can be triggered by different genetic mutations in genes involved in the proliferation and differentiation of T-cells.The identification and study of mutations found in leukemia patients is particularly important to help develop more efficient and targeted therapies.

Researchers now found a group of mutations that affect 9% of the patients with T-ALL and that may originate leukemia in these patients. Most importantly, researchers demonstrated that a set of pharmaceutical drugs can eliminate the effect of these mutations, unraveling a potential therapeutic application for their discovery.


Fourth Nature of this summer

This is the fourth article published by IMM researchers in the Nature publishing group since late July. Cancer, gene expression, neurodegenerative diseases were the topics that were published in this prestigious group of scientific publications, enhancing the quality of biomedical research in Portugal, and in particular, IMM.

Two other works developed at the Institute of Molecular Medicine, this time by the team led by researcher Maria do Carmo Fonseca, were published this summer in the journal Nature Structural & Molecular Biology (published on 26 July and 4 September). In these two articles, the researchers show a new form of regulation of gene expression, which changes in part to the classical perspective of how the information contained in genes is regulated for the proper functioning of body cells. Tiago F. Outeiro, in turn, published in the journal Nature Chemical Biology.

source: www.imm.fm.ul.pt

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Index - News # 23 | set/out. 2011
 Editorial Note
 FMUL – Participation in the Medical Knowledge Test_Mod. NBME
 The universities of Lisbon and the Future – Professor J. Fernandes e Fernandes article
 Clarification about Carreer Progression of Academics at the Univ. of Lisbon-Rector A. Sampaio Nóvoa
 Faculty of Medicine of the University of Lisbon signs protocols with Universities in Brazil
 2011 Nobel Prize for Medicine awarded to three scientists for discoveries on the immune system
 A brief look at my term of office as Deputy Director (2005-2011) of FMUL and Expectations of the Faculty for the Future
 Interview with Diana Andrade Silva
 Last lesson by Professor Joaquim Alexandre Ribeiro
 International partnership IMM-INSERM organizes workshop in Bioimaging
 Presentation session on the Repository of the University of Lisbon
 The Family in General and Family Medicine – Concepts and Practices – Professor Luis Rebelo
 Conference on Hospital Reform
 Inauguration of the Doctor Eduardo Coelho Study Room
 The Northern Lisbon Hospital Centre and the Building of the Academic
 School Material and Children’s Book Collection Campaign
 Project 172 wins 4th edition of the SB of the Lisbon City Hall
 Welcome to FMUL 2011/2
 Livro do Mês de Outubro
 Study led by João Barata leads to Vote of Congratulations to Portuguese scientific research
 New genetic mutations in leukemia: IMM researchers found molecular mechanism that can help design future targeted therapies
 IMM researcher funded to study immune response impairing hemophilia treatment
 IMM-INSERM Doctors Exchange Programme
 Academic Examinations at the Faculty Of Medicine of The University of Lisbon
 School Material and Children’s Book Collection Campaign
 International Intercampus: The Relevance of a Research Training in Clinical Nutrition
 There is no party like this one
 Secretariat International Day – Lunch gathering organized by CPA
 Science and Health Research
 MARKING EXAMINATIONS BY OPTICAL READING (OCR)
 Lançamento do Livro “A Faculdade de Medicina de Lisboa – Um Olhar sobre a sua História”
 Debates de Reflexão da AAAFML – 17 de Novembro
 Eleições da AAAFML – 17 de Novembro
 Encontro de Técnicos de Diagnóstico e Terapêutica – 12 de Novembro
 Banco Alimentar Contra a Fome – 27 e 28 de Novembro
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100 AnosPropriedade e Edição: Faculdade de Medicina da Universidade de Lisboa NIPC: 502662875  Periodicidade: Mensal  Diretor: Prof. Doutor Fausto J. Pinto Conselho Editorial: Prof. Doutor Fausto J. Pinto, Profª. Doutora Ana Sebastião, Prof. Doutor Mamede de Carvalho, Prof. Doutor António Vaz Carneiro, Prof. Doutor Miguel Castanho, Dr. Luís Pereira  Equipa Editorial:  Ana Raquel Moreira, Cristina Bastos, Isabel Varela, Joana Sousa, Maria de Lurdes Barata, Rui Gomes, Sónia Teixeira  Colaboração:  Gabinete de Relações Públicas, Internacionais e Comunicação  Versão Inglesa: AP|PORTUGAL- Language Services  Conceção: Metatexto, Lda. e-mail: news@medicina.ulisboa.pt  Sede do Editor e Sede da Redação: Avenida Prof. Egas Moniz, 1649-028 Lisboa Estatuto Editorial Anotado na ERC 

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