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Dopamine and Parkinson’s Disease: IMM and Harvard Medical School Researchers reveal Molecular Clues

By etavares On 30 September, 2009 Research and Advanced Education | 2009 Comments Off on Dopamine and Parkinson’s Disease: IMM and Harvard Medical School Researchers reveal Molecular Clues No tags

On the 4th of September, in the prestigious magazine PloS One, Tiago Fleming Outeiro, head of the Unit of Cell and Molecular Neurosciences at the Institute of Molecular Medicine (IMM) published, along with researchers from the USA, a study that shows new clues about the action of dopamine, a central nervous system stimulant, on Parkinson’s disease.

The study was carried out at Harvard Medical School (USA) and at the IMM, and had the collaboration of Portuguese, American and German researchers.

Parkinson’s disease is characterised by the degeneration and death of neurons in a region of the brain, the substancia nigra.

Despite one not knowing about important aspects of the molecular mechanisms responsible for the disease, it is known that at its base is the formation of protein aggregate within the neurons, namely a small protein called alfa-synuclein. In the neurons of Parkinson’s disease sufferers the alfa-synuclein takes on an altered form, which provokes its aggregation into agglomerates that are toxic for the cells.

The study now published shows that the alterations in form suffered by alfa-synuclein may be induced by dopamine, suggesting a role by dopamine in the formation of the protein aggregates characteristic to Parkinson’s disease. Dopamine is a central nervous system stimulant, a precursor of adrenalin and noradrenalin, involved in psychological dependence on several vices and in the degeneration of the neurons in Parkinson’s disease. The results published today also provide a possible explanation for previous observations, which revealed that the neurons producing/receiving dopamine are more vulnerable to the cell death characteristic to Parkinson’s disease.

“Our work suggests that the vulnerability of neurons in Parkinson’s disease is related to dopamine’s capacity to favour forms of alfa-synuclein that lead to the appearance of protein aggregates”, states Tiago Fleming Outeiro, the first author of the study and IMM researcher. “In this work we have identified these specific forms of alfa-synuclein; we now hope that our results might allow us to better understand the molecular mechanism that leads to Parkinson’s disease, as well as to find new forms of prevention or therapy”, continues Tiago Fleming Outeiro.

 

Unit of Communication and Training
Institute of Molecular Medicine
ucom@fm.ul.pt

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Index - News # 8 | ago/set. 2009
 From Assessment to Training, Preparing the Future
 AGRIPUL – Action against Pandemic Flu in the University of Lisbon
 Sun, Photo-ageing and Skin Cancer
 II Refresher Course on Tuberculosis and AIDS
 The FMUL CDI Library in the Paradigm of the Digital Age
 FMUL Museum of Medicine
 VII Encontro Anual da Engenharia Biomédica
 From the Laboratory to the Stage to show Science
 ENJOY Med – National Encounter of Young Medicine Students
 The Egas Moniz Building and the New Demands for Energy Efficiency
 Health Practice in the Community – Successful Training Periods – 1st and 2nd Year Students in Health Centres
 Evaluation of Performance – Faculty of Medicine of the University of Lisbon
 Book of the Month
 Dopamine and Parkinson’s Disease: IMM and Harvard Medical School Researchers reveal Molecular Clues
 Concurso ao 13º Programa “Educação pela Ciência”
 Teacher Participation on Juries for Academic Assessment in other Institutions
 Geriatric and Palliative Care
 Comments and Suggestions
 Indicators of the 12th “Education through Science” – Programme – 2008/2009
 Advanced Training Grants awarded to PhD Students at the FMUL
 Research Integration Grants Awarded to FMUL Students
 Welcome to the FMUL 2009/2010
 PFIZER Research Prize 2009
 6th Competition for the AstraZeneca Foundation / FMUL Research Grant
 Introduction Week to the Medicine Course
 Brochure “FMUL 2009/2010 – Medical Integrated Master Course”
 Are you interested in Guidelines? Two International Meetings in Our School, in Lisbon
 Doctors on the Big Screen
 EURASNET – Workshop “Splicing in Cell Biology”
 European Depression Day
 23rd Khwarizmi International Award (KIA)
 APTFeridas Congress 2009
 Agency for Evaluation and Accreditation of Higher Education (A3ES)
 O Futuro de Bolonha, 10 Anos Depois
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100 AnosPropriedade e Edição: Faculdade de Medicina da Universidade de Lisboa NIPC: 502662875  Periodicidade: Mensal  Diretor: Prof. Doutor Fausto J. Pinto Conselho Editorial: Prof. Doutor Fausto J. Pinto, Profª. Doutora Ana Sebastião, Prof. Doutor Mamede de Carvalho, Prof. Doutor António Vaz Carneiro, Prof. Doutor Miguel Castanho, Dr. Luís Pereira  Equipa Editorial:  Ana Raquel Moreira, Cristina Bastos, Isabel Varela, Joana Sousa, Maria de Lurdes Barata, Rui Gomes, Sónia Teixeira  Colaboração:  Gabinete de Relações Públicas, Internacionais e Comunicação  Versão Inglesa: AP|PORTUGAL- Language Services  Conceção: Metatexto, Lda. e-mail: news@medicina.ulisboa.pt  Sede do Editor e Sede da Redação: Avenida Prof. Egas Moniz, 1649-028 Lisboa Estatuto Editorial Anotado na ERC 

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